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Research InterestsAssociate Professor Bill Sewell | | (Position Details) | | Phone 02 9295 8434 | | Email | | Qualifications BSc MB BS Syd, PhD Melb, FRCPA |
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| St Vincent's Clinical School | | http://stvcs.med.unsw.edu.au/
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| | Broad Research Areas | |
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Allergy
Immunology
Inflammation
Haematology
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| | | | Specific Research Keywords | |
| Cytokines
Allergy
T Cells
Molecular Mechanisms
Leukaemia
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| | | | Research Interests | |
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Major interest is molecular and cellular biology of allergic inflammation. Particular interests are: (1) Role of cytokines, including Th2 cytokines and GM-CSF, in the pathogenesis of asthma, other allergic diseases and parasite infection; (2) Role of eosinophils in these conditions; (3) In collaboration with A/Prof Andrew Collins, Biotechnology and Biomolecular Sciences, UNSW, investigation of immunoglobulin E sequences in allergy and parasitic infection; (4) In collaboration with the Pathology Department in St Vincent's Hospital, investigation of novel markers in leukaemia and lymphoma.
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| | | | ILP Research Interests (Will supervise ILP students) |
| Asthma
Immunology
Inflammation
Leukaemia
Lymphoma
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| | | | Project Topics for current Honours Students |
| In 2008, a BSc (Med) Hons student is researching the requirement for the cytokine GM-CSF in allergic inflammation. | |
| | | | Teaching Interests | |
| Significant contribution to teaching immunology and pathology to all stages of the UNSW Medical Curriculum and to 3rd year Science students, and a variety of post-graduate audiences. Is highly skilled in teaching all areas of immunology to undergraduates. Has served for five years as co-convenor of Society and Health in Phase 1 of the UNSW Medical Curriculum. Special expertise in imparting an understanding of the medical implications of basic research developments. | |
| | | | Society Memberships & Professional Activities | |
| Australian Society for Immunology, Australian Society for Allergy and Clinical Immunology, Australian Society of Medical Research, Clinical Cytometry Society
Member of Editorial Board of Immunology & Cell Biology
Member of Editorial Board of the On-line Allergy Journal
Member of Research Committee of Asthma Foundation of NSW | |
| | | | Funding Sources | |
| The laboratory has been funded by NH&MRC, the Asthma Foundation of NSW and the Faculty Research Grant Committee of the UNSW Faculty of Medicine. | |
| | | | Thesis topics for current UNSW Medicine postgraduate research students |
- To be advised.
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| | | | Other Postgraduate Research | |
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Has supervised 8 completed PhD students to successful completion and has examined over 30 PhD theses.
Served for 13 years as Post-Graduate Co-ordinator for St Vincent's Clinical School, covering nearly all PhD students at the Garvan Institute and Victor Chang Cardiac Research Institute. Highly experienced in administration of post-graduate students. | |
| | | | Key works/Publications | |
| SELECTED RECENT PUBLICATIONS
Su, Y.-C., M. S. Rolph, M. A. Cooley, W. A. Sewell. (2006) Cyclophosphamide Augments Inflammation by Reducing Immunosuppression in a Mouse Model of Allergic Airway Disease. J Allerg Clin Immunol 117: 635-641.
Dahlke, I., D. J. Nott, J. Ruhno, W. A. Sewell & A. M. Collins. (2006) Antigen selection in the IgE response of allergic and non-allergic individuals. J Allerg Clin Immunol 117: 1477-83.
Belov, L., S. P. Mulligan, N. Barber, P. Huang, J. S. Chrisp, D. S. Pascovici, M. Thomas, W. A. Sewell, et al. (2006) Analysis of human leukemias and lymphomas using extensive immunophenotypes from an antibody microarray. Br. J. Haematol. 135: 184-197.
Lee, C. E. H., Jackson, K. J. L., Sewell, W. A. and A. M. Collins. (2007) Use of IGHJ and IGHD gene mutations in analysis of immunoglobulin sequences for the prognosis of chronic lymphocytic leukemia. Leuk. Res. 31:1247-52.
Yan, W., K. J. L. Jackson, W. A. Sewell & A. M. Collins. (2008) The human immunoglobulin heavy chain gene repertoire contains relatively few IGHV gene polymorphisms. Immunol. Cell Biol. 86: 111-115.
Su, Y.-C., M. S. Rolph, N. G. Hansbro, C. R. Mackay & W. A. Sewell. (2008) Granulocyte-macrophage colony–stimulating factor is required for bronchial eosinophilia in a murine model of allergic airway inflammation. J. Immunol. 180: 2600-2607.
Shum, B. O. V., M. S. Rolph & W. A. Sewell. (2008) Mechanisms in allergic airway inflammation – lessons from studies in the mouse. Expert Rev. Mol. Med. 10(15):1-18.
Tumes, D. J., Wong, A. C. H., Sewell, W. A., McColl, S. R. , Connolly, A. and Dent, L. A. (2008) Differential Rates of Apoptosis and Recruitment Limit Eosinophil Accumulation in the Lungs of Asthma-Resistant CBA/Ca Mice. Mol Immunol 45: 3609-17.
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